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Life

Life's other mystery: Why biology's building blocks are so lop-sided

Most molecules exist in mirror-image forms, and yet life prefers one over the other. How this bias began and why it persisted is one of the most baffling questions in biology – but now we have an answer

By Hayley Bennett

15 April 2020

×îÐÂÂé¶¹ÊÓÆµ. Science news and long reads from expert journalists, covering developments in science, technology, health and the environment on the website and the magazine.

Peter Strain

LIFE can be strange. Just look at narwhals, and those stick insects that resemble leaves on legs. Or consider the cockeyed squid, with its bizarrely mismatched peepers: one yellow and huge, the other tiny and blue. And yet almost nothing about life is as baffling as the lopsidedness at its core.

All biological molecules have an inherent “handedness”: they can exist in two mirror-image forms, just like your left and right hands. But for each type of molecule it uses, life on Earth prefers a single form. So much so, in fact, that their opposite numbers are rarely seen…

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