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Humans

Exercise pills: Should we use drugs that mimic benefits of a workout?

Researchers are developing medicines that replicate the health benefits of exercise. In the process, they’re gaining insights into how to treat currently untreatable diseases

By Jo Marchant

21 April 2021

×îÐÂÂé¶¹ÊÓÆµ. Science news and long reads from expert journalists, covering developments in science, technology, health and the environment on the website and the magazine.

Martin Leon Barreto

RONALD EVANS never intended to kick off a performance-enhancing drug craze, but that is what happened. Despite a ban on its use in sports, the substance he has long been studying has now been detected in doping tests of cyclists and boxers, while runners and bodybuilders share stories online about how it makes them leaner and stronger nonetheless.

The story begins in 2002, when Evans, a biologist at the Salk Institute in La Jolla, California, performed some experiments involving mice and exercise wheels. He fed a drug known as GW1516 to unfit mice, expecting to see modest effects on their…

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